| UK | Opp | OTs | Date | School | Place | Event | All-Time |
| 37 | 13 | | 9/3/2022 | Miami (OH) | Lexington | | 9-4-1 |
| 26 | 16 | | 9/10/2022 | Florida | Gainesville, FL | | 20-53 |
| 31 | 0 | | 9/17/2022 | Youngstown State | Lexington | | 1-0 |
| 31 | 23 | | 9/24/2022 | Northern Illinois | Lexington | | 1-0 |
| 19 | 22 | | 10/1/2022 | Ole Miss | Oxford, MS | | 14-30-1 |
| 14 | 24 | | 10/8/2022 | South Carolina | Lexington | | 14-19-1 |
| 27 | 17 | | 10/15/2022 | Mississippi State | Lexington | | 25-25 |
| 6 | 44 | | 10/29/2022 | Tennessee | Knoxville, TN | | 26-83-9 |
| 21 | 17 | | 11/5/2022 | Missouri | Columbia, MO | | 9-4 |
| 21 | 24 | | 11/12/2022 | Vanderbilt | Lexington | | 48-43-4 |
| 6 | 16 | | 11/19/2022 | Georgia | Lexington | | 12-62-2 |
| 26 | 13 | | 11/26/2022 | Louisville | Lexington | | 19-15 |
| 0 | 21 | | 12/31/2022 | Iowa | Nashville, TN | TransPerfect Music City Bowl | 1-1 |